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Search: L773:0143 3334 > Mucci Lorelei A > Andersson Sven Olof 1949 > Molecular differenc...

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Molecular differences in transition zone and peripheral zone prostate tumors

Sinnott, Jennifer A. (author)
Department of Epidemiology, Harvard School of Public Health, Boston, USA; Department of Biostatistics, Harvard School of Public Health, Boston, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, USA
Rider, Jennifer R. (author)
Department of Epidemiology, Harvard School of Public Health, Boston, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, USA
Carlsson, Jessica, 1984- (author)
Örebro universitet,Institutionen för hälsovetenskap och medicin
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Gerke, Travis (author)
Department of Epidemiology, College of Medicine and College of Public Health and Health Professions, University of Florida, Gainesville, USA
Tyekucheva, Svitlana (author)
Department of Biostatistics, Harvard School of Public Health, Boston, USA; Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, USA
Penney, Kathryn L. (author)
Department of Epidemiology, Harvard School of Public Health, Boston, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, USA
Sesso, Howard D. (author)
Department of Epidemiology, Harvard School of Public Health, Boston, USA; Divisions of Preventive Medicine and Aging, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA
Loda, Massimo (author)
Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA; Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, USA
Fall, Katja, 1971- (author)
Örebro universitet,Institutionen för hälsovetenskap och medicin,Department of Epidemiology, Harvard School of Public Health, Boston, USA
Stampfer, Meir J. (author)
Department of Epidemiology, Harvard School of Public Health, Boston, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA
Mucci, Lorelei A. (author)
Department of Epidemiology, Harvard School of Public Health, Boston, USA
Pawitan, Yudi (author)
Karolinska Institutet
Andersson, Sven-Olof, 1949- (author)
Örebro universitet,Institutionen för hälsovetenskap och medicin
Andrén, Ove, 1963- (author)
Örebro universitet,Institutionen för hälsovetenskap och medicin
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 (creator_code:org_t)
2015-04-13
2015
English.
In: Carcinogenesis. - Oxford, United Kingdom : Oxford University Press. - 0143-3334 .- 1460-2180. ; 36:6, s. 632-638
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Prostate tumors arise primarily in the peripheral zone (PZ) of the prostate, but 20-30% arise in the transition zone (TZ). Zone of origin may have prognostic value or reflect distinct molecular subtypes; however, it can be difficult to determine in practice. Using whole-genome gene expression, we built a signature of zone using normal tissue from five individuals and found that it successfully classified nine tumors of known zone. Hypothesizing that this signature captures tumor zone of origin, we assessed its relationship with clinical factors among 369 tumors of unknown zone from radical prostatectomies (RPs) and found that tumors that molecularly resembled TZ tumors showed lower mortality (P = 0.09) that was explained by lower Gleason scores (P = 0.009). We further applied the signature to an earlier study of 88 RP and 333 transurethral resection of the prostate (TURP) tumor samples, also of unknown zone, with gene expression on ~6000 genes. We had observed previously substantial expression differences between RP and TURP specimens, and hypothesized that this might be because RPs capture primarily PZ tumors, whereas TURPs capture more TZ tumors. Our signature distinguished these two groups, with an area under the receiver operating characteristic curve of 87% (P < 0.0001). Our findings that zonal differences in normal tissue persist in tumor tissue and that these differences are associated with Gleason score and sample type suggest that subtypes potentially resulting from different etiologic pathways might arise in these zones. Zone of origin may be important to consider in prostate tumor biomarker research.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Keyword

Onkologi
Oncology

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ref (subject category)
art (subject category)

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